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Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.īuSpar is rapidly absorbed in man and undergoes extensive first-pass metabolism. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models.īuspirone has moderate affinity for brain D 2-dopamine receptors. In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT 1A) receptors. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. The mechanism of action of buspirone is unknown. The 30 mg tablet also contains iron oxide.
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BuSpar Tablets contain the following inactive ingredients: colloidal silicon dioxide, lactose, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. A single 30 mg tablet can provide the following doses: 30 mg (entire tablet), 20 mg (two thirds of a tablet), 15 mg (one half of a tablet), or 10 mg (one third of a tablet). Thus, a single 15 mg tablet can provide the following doses: 15 mg (entire tablet), 10 mg (two thirds of a tablet), 7.5 mg (one half of a tablet), or 5 mg (one third of a tablet). These tablets are scored so they can be either bisected or trisected. The 15 mg and 30 mg tablets are provided in the DIVIDOSE ® tablet design. Thus, the 5 mg tablet can also provide a 2.5 mg dose, and the 10 mg tablet can provide a 5 mg dose. The 5 mg and 10 mg tablets are scored so they can be bisected.
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You may report side effects to the FDA at 1-80.BuSpar is supplied as tablets for oral administration containing 5 mg, 10 mg, 15 mg, or 30 mg of buspirone hydrochloride, USP (equivalent to 4.6 mg, 9.1 mg, 13.7 mg, and 27.4 mg of buspirone free base, respectively). If you notice any other effects, check with your healthcare professional.Ĭall your doctor for medical advice about side effects. Other side effects not listed may also occur in some patients.
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Trouble with sleeping, nightmares, or vivid dreams Muscle pain, spasms, cramps, or stiffness Restlessness, nervousness, or unusual excitement
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Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.
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Some side effects may occur that usually do not need medical attention. Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdoseĭizziness or lightheadedness especially when getting up from a sitting or lying position suddenly Numbness, tingling, pain, or weakness in the hands or feet Check with your doctor immediately if any of the following side effects occur: Rare
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